Optimizing early Go/No Go decisions in CNS drug development
نویسندگان
چکیده
منابع مشابه
Essential CNS Drug Development
Introduction The intent of this chapter is to provide a conceptual framework for the rest of the book from both a historical and a forward-looking perspective. Like all of medicine, drug development in psychiatry began with a series of chance discoveries from the 1930s to the 1960s. These drugs in large measure validated the following psychiatric syndromes: manic-depressive illness or bipolar (...
متن کاملThe impending crisis in CNS drug development
A plethora of information has been gathered across the fields of neuroimaging, genetics/genomics, proteomics, neurobiology, and epidemiology that have greatly enhanced our basic knowledge of the pathophysiological and genetic underpinnings of many common central nervous system (CNS) disorders such as schizophrenia, Alzheimer’s disease (AD), Parkinson’s disease, depression, and anxiety disorders...
متن کاملThe current development of CNS drug research.
In the past few years, several high profiled pharmaceutical companies have decided to shut down major research activities within the central nervous system (CNS) area. For example, in December 2011 Novartis announced that the company is closing its neuroscience facility in Basel, Switzerland, where Novartis is headquartered (Abbott, 2011). It follows similar moves by GlaxoSmithKline and AstraZe...
متن کاملOptimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery.
In drug discovery, the potential of cytochrome P450 inhibition of new chemical entities is frequently quantified in terms of IC50 values. In early drug discovery, a risk classification into low, medium, or high potential inhibitors is often sufficient for ranking and prioritizing of compounds. Although often 6 or more inhibitor concentrations are used to determine the IC50 value, the question a...
متن کاملMembrane transporter proteins: a challenge for CNS drug development
Drug transporters are membrane proteins present in various tissues such as the lymphocytes, intestine, liver, kidney, testis, placenta, and central nervous system. These transporters play a significant role in drug absorption and distribution to organic systems, particularly if the organs are protected by blood-organ barriers, such as the blood-brain barrier or the maternal-fetal barrier. In co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Review of Clinical Pharmacology
سال: 2014
ISSN: 1751-2433,1751-2441
DOI: 10.1586/17512433.2015.991715